How do Other Cannabinoids Stack when Compared to CBD

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CBD has hit the market by storm and it doesn’t seem like it is going to be stopping anytime soon. But, what about the other cannabinoids? We have heard that there are more than 113 different kinds of cannabinoids found in both hemp and marijuana plants.

These cannabinoids are specifically called phytocannabinoids because they come from a plant. Endocannabinoids are cannabinoids that are made within our bodies.

With so many different types of cannabinoids, it is only natural to wonder if they have any positive or negative impact on our bodies.

CBD and THC are the two most researched cannabinoids; however, there are several others that have been identified, extracted, and researched.

So, we are going to find out how other cannabinoids stack when compared to CBD.

How are Cannabinoids Made?

Unfortunately, cannabis does not directly make the infamous cannabinoids we have heard so much about such as THC and CBD. Instead, it synthesizes various cannabinoid acids. The acids in the plant must be activated through decarboxylation.

Decarboxylation merely means to heat up to yield the compounds such as THC or CBD. In addition to THCA and CBDA acids, there are several other cannabinoid acids that can go through this process to become cannabinoids. These are:

  • CBGA (Cannabigerolic acid)
  • THCA (tetrahydrocannabinolic acid)
  • CBDA (Cannabidiolic acid)
  • CBCA (Cannabichromene acid)
  • CBGVA (Cannabigerovarinic acid)
  • THCVA (Tetrahydrocannabivarin acid)
  • CBDVA (Cannabidivarinic acid)
  • CBCVA (Cannabichromevarinic acid)

When the above cannabinoid acids are exposed to heat, they lose the “A” part and become neutral instead of acidic changing them into cannabinoids.

What are the Other Cannabinoids?

Once cannabis is heated up, research has said it has more than 100 cannabinoids. However, it is difficult to say exactly how many because most of them are at very low levels in the plant. Therefore, scientists have a hard time detecting them.

What is extremely important is that there are many, and out of them we know that at least 8 of them have medicinal properties. Here are the cannabinoids we are able to detect currently:

  • CBG (Cannabigerol)
  • THC (tetrahydrocannabinol)
  • CBD (Cannabidiol)
  • CBC (Cannabichromene)
  • CBGV (Cannabigerivarin)
  • THCV (Tetrahydrocannabivarin)
  • CBDV (Cannabidivarin)
  • CBCV (Cannabichromevarin)

Will These Other Cannabinoids Make You High?

The short answer is no! The only cannabinoid we have found that gives you the “high” feeling is THC. This is why CBD has taken the market by storm. Not only does it provide a multitude of health benefits, but it also doesn’t alter your brain function.

How do They Stack Compared to CBD?

When it all boils down, research has found that although CBD is great isolated that cannabinoids work better together. This includes all cannabinoids found in the cannabis plant. Therefore, when each is isolated on its own, we do not have as great effects as we do when they are used together.

The Entourage Effect

If you look at the buds on cannabis, you will see a plethora of sticky dusting crystal resin. This resin contains 100s of cannabinoids and each of them used as a whole plant is more effective than separately. This is called the entourage effect.

The diversity of cannabinoids available in cannabis is remarkable, to say the least, but research is really delving into how cannabinoids work together. Here are just a few things research has found:

  • Terpene myrcene can reduce the resistance in the blood-brain barrier making an easier passage of other chemicals and cannabinoids.
  • Pinene helps counteract the compromised cognition and memory that is caused by THC alone.
  • The combination of pinene, myrcene, and caryophyllene help alleviate anxiety more effectively.
  • Mixing terpenes linalool and limonene with CBG can help treat MRSA.
  • CBD and THC work together to enhance sedation.
  • Linalool and limonene with CBD can be used as an acne treatment.
  • Fatty acids are found throughout the whole plant and are a great source of nutrients to our body.

These examples of how the whole plant works together for overall healthy merely scratch the surface of what they can do. There are tons of medical possibilities waiting for us to discover them.

However, we have only just begun our research into cannabis. There are still many more cannabinoids, vitamins, and nutrients that we need to research and understand for it to all fit together.

Related: Full Spectrum CBD Oil VS CBD Isolate

The Cannabinoids and Their Effects

Although cannabinoids work better together, we can pull out benefits from each type of cannabinoid we have researched. Here is what we have discovered about the top cannabinoids we have been able to research:


THC is a partial agonist at the CB1 and CB2 receptors of the endocannabinoid system. It is a mild analgesic, painkiller, and has antioxidant activity.

It holds the most COX-1 and COX-2 inhibitors making it anti-inflammatory, antiproliferative, and antispasmodic


CBD is another cannabinoid most people are familiar with. It directly inhibits the COX-2 enzyme aiding in reducing inflammation.

Although it has a plethora of medicinal benefits such as pain relief, inflammation reduction, homeostasis of cells, treatment of ADHD, and more, it has a low binding affinity to both CB1 and CB2 on its own.

Related: 20 Amazing Benefits of CBD Oil


CBN is produced from the degradation of THC, therefore, it is mildly psychoactive. There is very little CBN found in cannabis plants.

This is the cannabinoid that gives you more of a sedative effect. It has a greater chance of binding with CB2 receptors than CB1 receptors.


CBG is a non-psychoactive cannabinoid. It has antibacterial effects. It kills or slows bacterial growth, reduces inflammation, inhibits cell growth in tumor and cancer cells, and promotes bone growth.


CBC is typically found in tropical cannabis plants. It is known to help alleviate pain, reduce inflammation, inhibit cell growth in tumors and cancer cells, and promote bone growth. It appears these cannabinoids are mediated through non-cannabinoid receptor interactions.


THCV is not found in all cannabis plants. It is closely related to THC but is structurally different. Although it is a subtle difference, this structural change provides a reduction in panic attacks, suppresses appetite, and promotes bone growth.


CBDV is like CBD, but again, has a structural difference that changes how it affects the body. Recent studies have shown that CBDV helps in the management of epilepsy due to its action at the TRPV1 receptors and modulation of gene expression.

So, how do these other cannabinoids stack compared to CBD? Well, it seems that each cannabinoid has something to offer.

Because Cannabinoids are found to work better together, Nuvelio Naturals uses the whole plant in their full-spectrum CBD oil tincture meaning you get all the benefits and none of the psychoactive effects.

What do you think? Should CBD and other cannabinoids be isolated or should we pack all the benefits into one bottle? Share your opinions in the comments below! 

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